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Thanks for writing in with your question.
Ideally you will would not start the ME till you were no longer aerobically deficient. But this plan is not designed to cure ADS. It is designed to prepare you for your first ultra run. Improving ME before you do that race is critical if you hope to have any kind of a race. So a person who does have ADS will still need this ME training. If you have ADS and do nothing but very slow training and then try to race off that program you will be disappointed.
If your goal is to just cure ADS then I would modify that plan to doing the Z2 work, hill sprints and replace the ME with a strength building program.
Scott